Spic Antibodies

AND Spic ELISA kits, Spic Proteins

Many biological assays use antibodies to detect Spic, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Spic in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Spic antibodies...

We validate the specificity of these antibodies to Spic by testing them on tissues known to express Spic positively and negatively. Browse below to find the Spic antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Spic Infographic by Boster Bio

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SPIC (NM_152323) Human Over-expression Lysate

Human

$628
Cat # LS121599
20 µg, 100 µg

Spic Overview

Facts about Transcription factor Spi-C.

Transcription factor Spi-C (Spic)

Controls the maturation of red pulp macrophages needed for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer.

Regulates VCAM1 gene expression. .

Gene Information

Mouse
Gene Name:	Spic
Uniprot:	Q6P3D7
Entrez:	20728

Family

Belongs to:

ETS family

Alternative Names

MGC40611; Spi-C transcription factor (Spi-1/PU.1 related); SPI-C; transcription factor Spi-C

Molecular Weight

Mass (kDA):
27.942 kDA

Genomic Context


Mouse

Location:	10\|10 C1
Sequence:	10;

Tissue Specificity

Expressed in lymphoid tissues, including spleen, bone marrow and thymus. According to PubMed:19037245, highly expressed in red pulp macrophages and, at lower, levels in B-cells, but not in other cells, including, monocytes, dendritic cells and other tissue macrophages. According to PubMed:10464163 expressed in pre- and mature B-cells but not in immature B-cells; according to PubMed:10187812 not expressed in pre- but predominantly in mature B-cells and at lower levels in macrophages.

Diseases

Salmonella Infections
Cardiomyopathy, Familial Idiopathic
Cardiomyopathy, Dilated
Cardiomyopathies
Systemic Infection
Malignant Neoplasms
Heart Failure
Salmonella Infections, Animal
Peritoneal Carcinomatosis
Dilatation Ventricular
Carcinoma
Cardiac Fibrillation
Carcinomatosis

Left Bundle-branch Block
Peritoneal Neoplasms
Cardiac Arrhythmia
Atrial Fibrillation
Pathological Dilatation
Tachycardia, Ventricular
Bundle-branch Block

Pathways

Secretion
Virulence
Immune Response
Localization
Cell Differentiation
B Cell Differentiation
Pathogenesis
Transposition
Spore Germination
Phagosome-lysosome Fusion
Cell Development
Fertilization

Humoral Immune Response
Follicular B Cell Differentiation
Phagocytosis
Cell Growth
Germination
Rna Interference

PTMs

Phosphorylation

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Spic

References

PMID: 10187812 by Bemark M., et al. Spi-C, a novel Ets protein that is temporally regulated during B lymphocyte development.

PMID: 10464163 by Hashimoto S., et al. Prf, a novel Ets family protein that binds to the PU.1 binding motif, is specifically expressed in restricted stages of B cell development.