SRD5A1 Antibodies

AND SRD5A1 ELISA kits, SRD5A1 Proteins

Many biological assays use antibodies to detect SRD5A1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SRD5A1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SRD5A1 antibodies...

We validate the specificity of these antibodies to SRD5A1 by testing them on tissues known to express SRD5A1 positively and negatively. Browse below to find the SRD5A1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for SRD5A1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the SRD5A1 Western Blot Guide

SRD5A1 Infographic by Boster Bio

All SRD5A1 Products

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Anti-SRD5A1 Antibody Picoband®

Western blot analysis of SRD5A1 using anti-SRD5A1 antibody (A03464-2)

Flow Cytometry analysis of PC-3 cells using anti-SRD5A1 antibody (A03464-2)

Flow Cytometry analysis of RH35 cells using anti-SRD5A1 antibody (A03464-2)

Human, Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A03464-2
100 μg/vial

SRD5A1 Overview

Facts about 3-oxo-5-alpha-steroid 4-dehydrogenase 1.

SRD5A1 3D structure. Source: alphafold

3-oxo-5-alpha-steroid 4-dehydrogenase 1 (SRD5A1)

Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.

Gene Information

Human
Gene Name:	SRD5A1
Uniprot:	P18405
Entrez:	6715

Family

Belongs to:

steroid 5-alpha reductase family

Alternative Names

3-oxo-5-alpha-steroid 4-dehydrogenase 1; EC 1.3.99.5,3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1; S5AR 1; SR type 1; Steroid 5-alpha-reductase 1,5-alpha reductase; steroid 5-alpha-reductase type I; steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta4-dehydrogenase alpha 1)

Molecular Weight

Mass (kDA):
29.459 kDA

Genomic Context


Human

Location:	5p15.31
Sequence:	5; NC_000005.10 (6633440..6674386)

Tissue Specificity

Liver and prostate (at a low level).

Subcellular Localizations

Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Diseases

Malignant Neoplasms
Malignant Neoplasm Of Prostate
Prostatic Neoplasms
Neoplasms
Neoplasm Metastasis
Neoplasms, Hormone-dependent
Malignant Neoplasm Of Breast
Mammary Neoplasms
Malignant Paraganglionic Neoplasm
Tumor Angiogenesis
Prostatic Hyperplasia
Tumor Progression

Bipolar Disorder
Hypertensive Disease
Virilism
Benign Prostatic Hypertrophy
Androgenetic Alopecia
Manic

Pathways

Cell Proliferation
Localization
Cell Growth
Angiogenesis
Pathogenesis
Cell Cycle
Parturition
Transport
Brain Development
Immune Response
Neurogenesis
Spermatogenesis

Cell Maturation
Cell Differentiation
Epithelial Cell Differentiation
Interphase
Cell Development
Dna Methylation
Ovulation

PTMs

Cleavage

Methylation

Research Areas

Lipid and Metabolism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SRD5A1

References

PMID: 2339109 by Andersson S., et al. Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases.

PMID: 1686016 by Jenkins E.P., et al. Characterization and chromosomal mapping of a human steroid 5 alpha- reductase gene and pseudogene and mapping of the mouse homologue.