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- Table of Contents
Serum response factor Antibodies
AND SRF ELISA kits, Serum response factor Proteins
Many biological assays use antibodies to detect Serum response factor, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Serum response factor in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Serum response factor antibodies...
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SRF Infographic by Boster Bio
All SRF Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA
$480
Cat # EKC1539
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1539
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2002
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2002
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00557-1
100 μg/vial
Cat # A00557-1
100 μg/vial
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00557-2
100 μg/vial
Cat # A00557-2
100 μg/vial
Human
$628
Cat # LS006722
20 µg, 100 µg
Cat # LS006722
20 µg, 100 µg
SRF Overview
Facts about Serum response factor.
Serum response factor (SRF)
SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp into the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration.
The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required for cardiac differentiation and maturation.
Gene Information
| Human | |
|---|---|
| Gene Name: | SRF |
| Uniprot: | P11831 |
| Entrez: | 6722 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
MCM1; serum response factor (c-fos serum response element-binding transcriptionfactor); serum response factor
Molecular Weight
Mass (kDA):
51.593 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6p21.1 |
| Sequence: | 6; NC_000006.12 (43171269..43181506) |
Subcellular Localizations
Nucleus.
Diseases
- Retinal Detachment
- Hypertrophy
- Neoplasms
- Malignant Neoplasms
- Leukemia
- Cholangiocarcinoma
- Rhegmatogenous Retinal Detachment
- Tissue Adhesions
- Cell Transformation, Neoplastic
- Fibrosis
- Proliferative Vitreoretinopathy
- Age Related Macular Degeneration
- Pathologic Neovascularization
Interacting Proteins
- GTF2F1
- MRTFA
- MRTFB
- MYOCD
Pathways
- Localization
- Cell Proliferation
- Cell Differentiation
- Cell Growth
- Cell Cycle
- Cell Migration
- Pathogenesis
- Muscle Cell Differentiation
- Transport
- Regeneration
- Aging
- Smooth Muscle Cell Differentiation
- Methylation
PTMs
- Phosphorylation
- Acetylation
- Methylation
- Cleavage
- Dephosphorylation
- Ubiquitination
- Sumoylation
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SRF
bosterbio.com/bosterbio-gene-info-cards/SRF
References
PMID: 3203386 by Norman C., et al. Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element.
PMID: 8375385 by Janknecht R., et al. C-terminal phosphorylation of the serum-response factor.