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- Table of Contents
Serglycin Antibodies
AND SRGN ELISA kits, Serglycin Proteins
Many biological assays use antibodies to detect Serglycin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Serglycin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Serglycin antibodies...
Designing a Western blot for Serglycin? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SRGN Western Blot GuideSRGN Infographic by Boster Bio
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SRGN Overview
Facts about Serglycin.
Serglycin (SRGN)
Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in the connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes.
Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B that's delivered to cells by perforin to cause apoptosis.
Gene Information
| Human | |
|---|---|
| Gene Name: | SRGN |
| Uniprot: | P10124 |
| Entrez: | 5552 |
Family
| Belongs to: |
|---|
| serglycin family |
Alternative Names
FLJ12930; Hematopoetic proteoglycan core protein; MGC9289; P.PG; Platelet proteoglycan core protein; platelet proteoglycan protein core; PPG; PRG1p.PG; PRGhematopoetic proteoglycan core peptide; proteoglycan 1, secretory granule; proteoglycan protein core for mast cell secretory granule; secretory granule proteoglycan 1; secretory granule proteoglycan core peptide; Secretory granule proteoglycan core protein; serglycin proteoglycan; Serglycin; SRGN
Molecular Weight
Mass (kDA):
17.652 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q22.1 |
| Sequence: | 10; NC_000010.11 (69057533..69104811) |
Subcellular Localizations
Cytoplasmic granule. Secreted, extracellular space. Golgi apparatus. Found in mast cell granules and in cytoplasmic granules of cytolytic T lymphocytes from where it is secreted upon cell activation (By similarity). Secreted constitutively by endothelial cells and macrophages (PubMed:11154222). Located to Golgi apparatus during neutrophil differentiation (PubMed:15136585).
Diseases
- Carcinoma
- Neoplasms
- Neoplasm Metastasis
- Neoplasm Invasiveness
- Acquired Immunodeficiency Syndrome
- Metastatic Malignant Neoplasm To The Liver
- Communicable Diseases
- Head And Neck Carcinoma
- Inflammatory Response
- Familial Hemophagocytic Lymphocytosis
- Head And Neck Neoplasms
- Renal Cell Carcinoma
Interacting Proteins
- GZMB
- SGTA
- UBQLN1
Pathways
- Secretion
- Regeneration
- Secretory Pathway
- Tissue Regeneration
- Phagocytosis
- Cell Death
- Anoikis
- Immune Response
- Glycosylation
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SRGN
bosterbio.com/bosterbio-gene-info-cards/SRGN
References
PMID: 2835370 by Stevens R.L., et al. Isolation and characterization of a cDNA that encodes the peptide core of the secretory granule proteoglycan of human promyelocytic leukemia HL-60 cells.
PMID: 2798108 by Stellrecht C.M., et al. Nucleotide sequence of a cDNA encoding a hemopoietic proteoglycan core protein.