This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
SRRT Antibodies
AND SRRT ELISA kits, SRRT Proteins
Many biological assays use antibodies to detect SRRT, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SRRT in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SRRT antibodies...
Designing an IHC experiment for SRRT? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SRRT IHC GuideSRRT Infographic by Boster Bio
All SRRT Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # A05444-1
100 µg/vial
Cat # A05444-1
100 µg/vial
SRRT Overview
Facts about Serrate RNA effector molecule homolog.
Serrate RNA effector molecule homolog (SRRT)
Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped main miRNA transcripts to the main miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs.
Binds capped RNAs (m7GpppG-capped RNA); nonetheless interaction is probably mediated via its interaction with NCBP1/CBP80 part of the CBC complicated. Involved in cell cycle progression at S phase.
Gene Information
| Human | |
|---|---|
| Gene Name: | SRRT |
| Uniprot: | Q9BXP5 |
| Entrez: | 51593 |
Family
| Belongs to: |
|---|
| ARS2 family |
Alternative Names
ARS2serrate; arsenate resistance protein 2; arsenate resistance protein ARS2; arsenite resistance protein; Arsenite-resistance protein 2; ASR2; MGC126427; serrate RNA effector molecule homolog (Arabidopsis); serrate RNA effector molecule homolog
Molecular Weight
Mass (kDA):
100.666 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q22.1 |
| Sequence: | 7; NC_000007.14 (100874971..100888664) |
Tissue Specificity
Ubiquitously expressed.
Subcellular Localizations
Nucleus, nucleoplasm. Cytoplasm. Predominantly nuclear. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent way (By similarity).
Diseases
- Neoplasm Metastasis
- Neoplasms
- Stomach Neoplasms
- Hereditary Diseases
- Primary Neoplasm
- Malignant Neoplasm Of Breast Staging
- Malignant Neoplasm Of Breast
- Metastatic Malignant Neoplasm To The Liver
- Schizophrenia
- Carcinogenesis
- Carcinoma
- Major Depressive Disorder
- Ataxia Telangiectasia
Interacting Proteins
- HTT
Pathways
- Mrna Splicing
- Cell Proliferation
- Cell Migration
- Translation
- Cell Cycle
- Cell Death
- S Phase
- Cell Differentiation
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SRRT
bosterbio.com/bosterbio-gene-info-cards/SRRT
References
PMID: 11239002 by Wilson M.D., et al. Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5.
PMID: 17693683 by Tang L.-Y., et al. Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.