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Part of the CREST-BRG1 complicated, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex.
|Sequence:||20; NC_000020.11 (62143765..62182514)|
Ubiquitous; with lowest levels in spleen.
Nucleus. Chromosome, centromere, kinetochore. Localizes to nuclear bodies. Colocalizes with SGO1 at kinetochore (By similarity).