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- Table of Contents
Syntaxin-1A Antibodies
AND STX1A ELISA kits, Syntaxin-1A Proteins
Many biological assays use antibodies to detect Syntaxin-1A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Syntaxin-1A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Syntaxin-1A antibodies...
Designing a Western blot for Syntaxin-1A? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the STX1A Western Blot GuideSTX1A Infographic by Boster Bio
All STX1A Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IP, WB
$370
Cat # M01961-3
100 μl/vial
Cat # M01961-3
100 μl/vial
STX1A Overview
Facts about Syntaxin-1A.
Syntaxin-1A (STX1A)
Plays a role in hormone and neurotransmitter exocytosis (By similarity). Potentially involved in docking of synaptic vesicles at presynaptic active zones.
May mediate Ca(2+)- regulation of exocytosis acrosomal reaction in sperm. .
Gene Information
| Human | |
|---|---|
| Gene Name: | STX1A |
| Uniprot: | Q16623 |
| Entrez: | 6804 |
Family
| Belongs to: |
|---|
| syntaxin family |
Alternative Names
Brain Syntaxin; HPC-1; Neuron-specific antigen HPC-1; p35-1; STX1A; STX1P35-1; SYN1A; syntaxin 1A (brain); Syntaxin 1A; syntaxin-1A
Molecular Weight
Mass (kDA):
33.023 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q11.23 |
| Sequence: | 7; NC_000007.14 (73699210..73719673, complement) |
Tissue Specificity
Isoform 1 is highly expressed in embryonic spinal chord and ganglia and in adult cerebellum and cerebral cortex. Isoform 2 is expressed in heart, liver, fat, skeletal muscle, kidney and brain.
Subcellular Localizations
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome. Cell membrane. Colocalizes with KCNB1 at the cell membrane.; [Isoform 2]: Secreted.
Diseases
- Nervousness
- Williams Syndrome
- Cystic Fibrosis
- Fibrosis
- Diabetes Mellitus
- Diabetes Mellitus, Non-insulin-dependent
- Insulinoma
- Pheochromocytoma
- Schizophrenia
- Tetanus
- Alzheimer's Disease
- Dysequilibrium Syndrome
Interacting Proteins
- GOSR2
- NAPB
- SNAP29
- SNCA
- STX4
- SUMO1P1
- TXLNA
- VAMP2
Pathways
- Exocytosis
- Secretion
- Transport
- Membrane Fusion
- Localization
- Synaptic Vesicle Exocytosis
- Vesicle Docking
- Insulin Secretion
- Vesicle Fusion
- Synaptic Transmission
- Proteolysis
- Snare Complex Assembly
- Vesicle Transport
PTMs
- Cleavage
- Phosphorylation
- Palmitoylation
- Biotinylation
- Reduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/STX1A
bosterbio.com/bosterbio-gene-info-cards/STX1A
References
PMID: 7622072 by Zhang R.-D., et al. Cloning and sequence analysis of a cDNA encoding human syntaxin 1A, a polypeptide essential for exocytosis.
PMID: 9311751 by Osborne L.R., et al. Hemizygous deletion of the syntaxin 1A gene in individuals with Williams syndrome.