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- Table of Contents
STXBP1 Antibodies
AND STXBP1 ELISA kits, STXBP1 Proteins
Many biological assays use antibodies to detect STXBP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with STXBP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop STXBP1 antibodies...
Designing a Western blot for STXBP1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the STXBP1 Western Blot GuideSTXBP1 Infographic by Boster Bio
All STXBP1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # PB9819
100 μg/vial
Cat # PB9819
100 μg/vial
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M02351
100 μl/vial
Cat # M02351
100 μl/vial
STXBP1 Overview
Facts about Syntaxin-binding protein 1.
Syntaxin-binding protein 1 (STXBP1)
May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio.
Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.
Gene Information
| Human | |
|---|---|
| Gene Name: | STXBP1 |
| Uniprot: | P61764 |
| Entrez: | 6812 |
Family
| Belongs to: |
|---|
| STXBP/unc-18/SEC1 family |
Alternative Names
EIEE4; FLJ37475; hUNC18; MUNC18-1; NSEC1; N-Sec1; p67; Protein unc-18 homolog 1; Protein unc-18 homolog A; rbSec1; STXBP1; syntaxin binding protein 1; syntaxin-binding protein 1; SyntaxinBP1; Syntaxin-BP1; UNC18; unc18-1; UNC18A; unc-18A; UNC18neuronal SEC1
Molecular Weight
Mass (kDA):
67.569 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9q34.11 |
| Sequence: | 9; NC_000009.12 (127611912..127696029) |
Tissue Specificity
Brain and spinal cord. Highly enriched in axons.
Subcellular Localizations
Cytoplasm, cytosol. Membrane; Peripheral membrane protein.
Diseases
- Epilepsy
- Encephalopathies
- Early Infantile Epileptic Encephalopathy With Burst-suppression
- Infantile Spasms
- Haploinsufficiency
- Spasm
- Nervousness
- Diabetes Mellitus
- Epilepsies, Myoclonic
- Retinopathy Of Prematurity
- Partial Seizure
Interacting Proteins
- C19orf57
- HSPA8
- MEOX2
- PSEN1
- STX11
- STX19
- STX5
- TRIM38
Pathways
- Exocytosis
- Secretion
- Membrane Fusion
- Vesicle Docking
- Transport
- Localization
- Vesicle Fusion
- Pathogenesis
- Synaptic Vesicle Exocytosis
- Insulin Secretion
- Neurotransmitter Secretion
- Vesicle Transport
- Synaptic Transmission
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/STXBP1
bosterbio.com/bosterbio-gene-info-cards/STXBP1
References
PMID: 8824310 by Gengyo-Ando K., et al. A murine neural-specific homolog corrects cholinergic defects in Caenorhabditis elegans unc-18 mutants.
PMID: 9545644 by Swanson D.A., et al. Identification and characterization of the human ortholog of rat STXBP1, a protein implicated in vesicle trafficking and neurotransmitter release.