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- Table of Contents
Facts about ATP-dependent RNA helicase SUPV3L1, mitochondrial.
ATPase and ATP- dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the elimination of aberrantly shaped mRNAs and the rapid degradation of non technical processing intermediates.
Human | |
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Gene Name: | SUPV3L1 |
Uniprot: | Q8IYB8 |
Entrez: | 6832 |
Belongs to: |
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helicase family |
ATP-dependent RNA helicase SUPV3L1, mitochondrial; EC 3.6.1; EC 3.6.4.13; suppressor of var1 (S.cerevisiae) 3-like 1; Suppressor of var1 3-like protein 1; suppressor of var1, 3-like 1 (S. cerevisiae); SUV3-like protein 1; SUV3suppressor of var1, 3-like 1(SUV3)
Mass (kDA):
87.991 kDA
Human | |
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Location: | 10q22.1 |
Sequence: | 10; NC_000010.11 (69180234..69209093) |
Broadly expressed.
Nucleus. Mitochondrion matrix. Mitochondrion matrix, mitochondrion nucleoid.
PMID: 10453991 by Dmochowska A., et al. A human putative Suv3-like RNA helicase is conserved between Rhodobacter and all eukaryotes.
PMID: 12466530 by Minczuk M., et al. Localisation of the human hSuv3p helicase in the mitochondrial matrix and its preferential unwinding of dsDNA.