KICSTOR complex protein SZT2 (SZT2)

As part of the KICSTOR complex functions in the amino acid-sensing division of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and enables its interaction with GATOR2 and the RAG GTPases.

Functions upstream of the RAG GTPases and is required to negatively modulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and triggered.