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- Table of Contents
TARDBP Antibodies
AND TARDBP ELISA kits, TARDBP Proteins
Many biological assays use antibodies to detect TARDBP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TARDBP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TARDBP antibodies...
Designing a Western blot for TARDBP? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the TARDBP Western Blot GuideTARDBP Infographic by Boster Bio
All TARDBP Products
Product
Figures
Specificity
Applications
Price
Anti-TDP43 TARDBP Rabbit Monoclonal Antibody
2 Citations
Human, Mouse, Rat, Zebrafish
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M01001
100 μl
Cat # M01001
100 μl
Human, Mouse, Rat
ELISA, Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # A01001-3
100 µg/vial
Cat # A01001-3
100 µg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01001-2
100 μl/vial
Cat # M01001-2
100 μl/vial
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M01001-3
20μL, 40μL, 100μL, 200μL
Cat # M01001-3
20μL, 40μL, 100μL, 200μL
TARDBP Overview
Facts about TAR DNA-binding protein 43.
TAR DNA-binding protein 43 (TARDBP)
DNA and RNA-binding protein that regulates transcription and splicing. Involved in the regulation of CFTR splicing.
It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of the exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis.
Gene Information
| Human | |
|---|---|
| Gene Name: | TARDBP |
| Uniprot: | Q13148 |
| Entrez: | 23435 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
ALS10; ALS10TAR DNA-binding protein-43; TAR DNA binding protein; TARDBP; TDP43; TDP-43; TDP-43TAR DNA-binding protein 43
Molecular Weight
Mass (kDA):
44.74 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p36.22 |
| Sequence: | 1; NC_000001.11 (11012654..11030528) |
Tissue Specificity
Ubiquitously expressed. In particular, expression is high in pancreas, placenta, lung, genital tract and spleen.
Subcellular Localizations
Nucleus. Cytoplasm. Cytoplasm, Stress granule. Continuously travels in and out of the nucleus (PubMed:18957508). Localizes to stress granules in response to oxidative stress (PubMed:19765185).
Diseases
- Amyotrophic Lateral Sclerosis
- Sclerosis
- Primary Lateral Sclerosis
- Frontotemporal Lobar Degeneration
- Feline Urological Syndrome
- Dementia
- Neurodegenerative Disorders
- Nerve Degeneration
- Frontotemporal Dementia
- Motor Neuron Disease
- Tdp-43 Proteinopathies
- Sarcoma
- Neuropathology Disease
Interacting Proteins
- ATXN2
- IRAK2
- PPP1R15A
Pathways
- Pathogenesis
- Rna Processing
- Localization
- Transport
- Mrna Splicing
- Translation
- Cognition
- Rna Splicing
- Locomotion
- Protein Folding
- Cell Adhesion
- Aging
- Stress Granule Assembly
PTMs
- Ubiquitination
Research Areas
- Cell Cycle and Replication
- Chromatin Research
- DNA replication, Transcription, Translation and Splicing
- Epigenetics
- Immunology
- Mitochondrial Fusion Proteins
- Neurodegeneration
- Neuronal Cell Markers
- Neuroscience
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TARDBP
bosterbio.com/bosterbio-gene-info-cards/TARDBP
References
PMID: 7745706 by Ou S.-H.I., et al. Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs.
PMID: 17481916 by Strong M.J., et al. TDP43 is a human low molecular weight neurofilament (hNFL) mRNA- binding protein.
1 Publications of Boster TARDBP Antibodies & ELISA Kits
- PubMed ID: 31452277, Zhang Y,Yang C,Yang S,Guo Z.MiRNA-27a decreases ultraviolet B irradiation-induce...
*More publications can be found for each product on its corresponding product page