Transcriptional enhancer factor TEF-4 (TEAD2)

Transcription factor which plays an integral role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The crux of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its own regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its own regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.

Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'- GTGGAATGT-3').