TFB1M Antibodies

AND TFB1M ELISA kits, TFB1M Proteins

Many biological assays use antibodies to detect TFB1M, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TFB1M in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TFB1M antibodies...

We validate the specificity of these antibodies to TFB1M by testing them on tissues known to express TFB1M positively and negatively. Browse below to find the TFB1M antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TFB1M Infographic by Boster Bio

All TFB1M Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Human TFB1M Recombinant Protein

SDS-PAGE

$265
Cat # PROTQ8WVM0
Starting from 10ug

Anti-TFB1M Mouse Monoclonal Antibody [Clone ID: OTI6G4]

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TFB1M (Right lane) cDNA for 48 hrs and lysed

Human, Mouse, Rat

$523
Cat # M05773
100 µl

TFB1M (NM_016020) Human Over-expression Lysate

Human

$628
Cat # LS051106
20 µg, 100 µg

TFB1M Overview

Facts about Dimethyladenosine transferase 1, mitochondrial.

TFB1M 3D structure. Source: alphafold

Dimethyladenosine transferase 1, mitochondrial (TFB1M)

S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM.

Stimulates transcription independently of the methyltransferase activity. .

Gene Information

Human
Gene Name:	TFB1M
Uniprot:	Q8WVM0
Entrez:	51106

Family

Belongs to:

class I-like SAM-binding methyltransferase superfamily

Alternative Names

CGI75; CGI-75; dimethyladenosine transferase 1, mitochondrial; EC 2.1.1; EC 2.1.1.-; h-mtTFB; h-mtTFB1; homolog of yeast mitochondrial transcription factor B; hTFB1M; Mitochondrial 12S rRNA dimethylase 1; mitochondrial dimethyladenosine transferase 1; Mitochondrial transcription factor B1; mtTFB; mtTFB1; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 1; transcription factor B1, mitochondrial

Molecular Weight

Mass (kDA):
39.543 kDA

Genomic Context


Human

Location:	6q25.3
Sequence:	6; NC_000006.12 (155229871..155314497, complement)

Tissue Specificity

Ubiquitously expressed.

Subcellular Localizations

Mitochondrion.

Diseases

Complete Hearing Loss
Mitochondrial Diseases
Dysequilibrium Syndrome
Cardiomyopathies
Liver Diseases
Mitochondrial Dna Depletion
Non-neoplastic Disorder
Multiple Organ Failure
Cardiac Hypertrophy
Down Syndrome
Heart Block
Myxoid Cyst
Parkinson Disease

Nonalcoholic Fatty Liver Disease
Congenital Heart Defects
Malignant Neoplasms
Neoplasms
Fatty Liver
Congenital Abnormality
Glioblastoma

Interacting Proteins

TFAM

Pathways

Translation
Oxidative Phosphorylation
Mitochondrial Translation
Methylation
Aging
Rna Modification
Rrna Methylation
Cell Growth
Pathogenesis
Rna Interference
Transport
Protein Phosphorylation
Mitochondrial Rna Modification

Electron Transport
Electron Transport Chain
Proteolysis
Ribosome Assembly
Cardiac Conduction
Mitochondrial Dna Replication
Cellular Respiration

PTMs

Phosphorylation

Methylation

Research Areas

Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TFB1M

References

PMID: 11809803 by McCulloch V., et al. A human mitochondrial transcription factor is related to RNA adenine methyltransferases and binds S-adenosylmethionine.

PMID: 12068295 by Falkenberg M., et al. Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA.