Homeobox protein TGIF1 (TGIF1)

Binds to a retinoid X receptor (RXR) reactive element in the mobile retinol-binding protein II promoter (CRBPII- RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element.

Active transcriptional corepressor of SMAD2. Links that the nodal signaling pathway into the bifurcation of the forebrain and the establishment of ventral midline structures.