Tiam2 Antibodies

AND Tiam2 ELISA kits, Tiam2 Proteins

Many biological assays use antibodies to detect Tiam2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Tiam2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Tiam2 antibodies...

We validate the specificity of these antibodies to Tiam2 by testing them on tissues known to express Tiam2 positively and negatively. Browse below to find the Tiam2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Tiam2 Infographic by Boster Bio

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TIAM2 (NM_001010927) Human Over-expression Lysate

Human

$960
Cat # LS026230
20 µg, 100 µg

Tiam2 Overview

Facts about T-lymphoma invasion and metastasis-inducing protein 2.

T-lymphoma invasion and metastasis-inducing protein 2 (Tiam2)

Modulates the activity of RHO-like proteins and joins extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them.

Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and progress of the growth cone of embryonic hippocampal neurons.

Gene Information

Mouse
Gene Name:	Tiam2
Uniprot:	Q6ZPF3
Entrez:	24001

Family

Belongs to:

TIAM family

Alternative Names

FLJ41865; KIAA2016; SIF and TIAM1-like exchange factor; STEFTIAM-2; T-cell lymphoma invasion and metastasis 2; T-lymphoma invasion and metastasis-inducing protein 2

Molecular Weight

Mass (kDA):
192.567 kDA

Genomic Context


Mouse

Location:	17 A1\|17 1.99 cM
Sequence:	17;

Tissue Specificity

Expressed in fetal brain (at protein level). Expressed in the olfactory bulb, cortical plate of the cerebral cortex, caudate putamen, hippocampus, ependymal cells of the lateral surface of the lateral ventricles of the brain. Weakly expressed in heart, lung, liver, skeletal muscle, kidney and testis.

Diseases

Neoplasm Metastasis
Malignant Neoplasms
Lymphoma
T-cell Lymphoma
Cell Invasion
Tissue Adhesions
Neoplasm Invasiveness
Neoplasms
Neuroblastoma
Cholangiocarcinoma
Hepatitis B
Down Syndrome
Malignant Neoplasm Of Liver

Carcinoma
Nervousness
Cell Transformation, Neoplastic
Nasal And Nasal-type Nk/t-cell Lymphoma
Liver Carcinoma
Hepatitis
Malignant Paraganglionic Neoplasm

Pathways

Cell Migration
Localization
Regeneration
Actin Cytoskeleton Reorganization
Regulation Of Growth
Neuron Development
Pathogenesis

Rna Interference

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Tiam2

References

PMID: 10364228 by Hoshino M., et al. Identification of the stef gene that encodes a novel guanine nucleotide exchange factor specific for Rac1.

PMID: 10512681 by Chiu C.-Y., et al. Cloning and characterization of T-cell lymphoma invasion and metastasis 2 (TIAM2), a novel guanine nucleotide exchange factor related to TIAM1.