TLE3 Antibodies

AND TLE3 ELISA kits, TLE3 Proteins

Many biological assays use antibodies to detect TLE3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TLE3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TLE3 antibodies...

We validate the specificity of these antibodies to TLE3 by testing them on tissues known to express TLE3 positively and negatively. Browse below to find the TLE3 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TLE3 Infographic by Boster Bio

All TLE3 Products

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Anti-TLE3 Antibody

Human, Mouse, Rat

ELISA, IP, IF, IHC, ICC, WB

$370
Cat # A04315-1
100 μl/vial

TLE3 Overview

Facts about Transducin-like enhancer protein 3.

TLE3 3D structure. Source: alphafold

Transducin-like enhancer protein 3 (TLE3)

Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling.

The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). .

Gene Information

Human
Gene Name:	TLE3
Uniprot:	Q04726
Entrez:	7090

Family

Belongs to:

WD repeat Groucho/TLE family

Alternative Names

ESG3; ESG3Enhancer of split groucho-like protein 3; ESGenhancer of split groucho 3; Grg3; HsT18976; KIAA1547FLJ39460; TLE3; transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila); transducin-like enhancer of split 3, homolog of Drosophila E(sp1); transducin-like enhancer protein 3

Molecular Weight

Mass (kDA):
83.417 kDA

Genomic Context


Human

Location:	15q23
Sequence:	15; NC_000015.10 (70047790..70098171, complement)

Tissue Specificity

Placenta and lung.

Subcellular Localizations

Nucleus.

Diseases

Neoplasms
Malignant Neoplasms
Malignant Neoplasm Of Breast
Mammary Neoplasms
Nervousness
Pituitary Diseases
Idiopathic Hypereosinophilic Syndrome
Leukemia
Leukemia, B-cell
Burkitt Lymphoma
Metaplasia
Meningeal Disorder

Uterine Cervical Neoplasm
Pre-eclampsia
Carcinogenesis
Carcinoma
Insulin Resistance
Neoplasms, Glandular And Epithelial

Pathways

Notch Signaling Pathway
Pathogenesis
Endocrine Pancreas Development
Cell Proliferation
Pancreas Development
Ear Development
Delamination
Cell Differentiation

Regulation Of Cell Differentiation
Transdifferentiation
Cell Maturation

PTMs

Phosphorylation

Methylation

Research Areas

Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TLE3

References

PMID: 1303260 by Stifani S., et al. Human homologs of a Drosophila enhancer of split gene product define a novel family of nuclear proteins.

PMID: 10748198 by Wang J.-C., et al. Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta.