TMCC1 Antibodies

AND TMCC1 ELISA kits, TMCC1 Proteins

Many biological assays use antibodies to detect TMCC1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TMCC1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TMCC1 antibodies...

We validate the specificity of these antibodies to TMCC1 by testing them on tissues known to express TMCC1 positively and negatively. Browse below to find the TMCC1 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TMCC1 Infographic by Boster Bio

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TMCC1 Overview

Facts about Transmembrane and coiled-coil domains protein 1.

TMCC1 3D structure. Source: alphafold

Transmembrane and coiled-coil domains protein 1 (TMCC1)

Endoplasmic reticulum membrane protein that boosts endoplasmic reticulum-associated endosome fission (PubMed:30220460). Localizes to contact sites between the endoplasmic reticulum and endosomes and functions by promoting recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460).

Endosome membrane fission of early and late endosomes is essential to separate areas destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). .

Gene Information

Human
Gene Name:	TMCC1
Uniprot:	O94876
Entrez:	23023

Family

Belongs to:

TEX28 family

Alternative Names

DKFZp686M0169; FLJ42680; KIAA0779; transmembrane and coiled-coil domain family 1; transmembrane and coiled-coil domains 1; transmembrane and coiled-coil domains protein 1

Molecular Weight

Mass (kDA):
72.083 kDA

Genomic Context


Human

Location:	3q22.1
Sequence:	3; NC_000003.12 (129647792..129893711, complement)

Subcellular Localizations

Endoplasmic reticulum membrane; Multi-pass membrane protein. Specifically localizes to contact sites between the endoplasmic reticulum and endosomes that are spatially and temporally linked to endosome fission.

Diseases

Facial Paralysis
Facial Nerve Diseases
Paresis

PTMs

Acetylation

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TMCC1

References

PMID: 24454821 by Zhang C., et al. Transmembrane and coiled-coil domain family 1 is a novel protein of the endoplasmic reticulum.

PMID: 30220460 by Hoyer M.J., et al. A novel class of ER membrane proteins regulates ER-associated endosome fission.