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- Table of Contents
Tomoregulin-2 Antibodies
AND TMEFF2 ELISA kits, Tomoregulin-2 Proteins
Many biological assays use antibodies to detect Tomoregulin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Tomoregulin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Tomoregulin-2 antibodies...
Designing a Western blot for Tomoregulin-2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the TMEFF2 Western Blot GuideTMEFF2 Infographic by Boster Bio
All TMEFF2 Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M03846-2
100 μl/vial
Cat # M03846-2
100 μl/vial
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M03846-4
100 μg
Cat # M03846-4
100 μg
TMEFF2 Overview
Facts about Tomoregulin-2.
Tomoregulin-2 (TMEFF2)
May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by encouraging ERK1/2 phosphorylation.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | TMEFF2 |
| Uniprot: | Q9UIK5 |
| Entrez: | 23671 |
Family
| Belongs to: |
|---|
| tomoregulin family |
Alternative Names
CT120.2; HPP1member 2; Hyperplastic polyposis protein 1; TENB2; TMEFF2; Tomoregulin2; Tomoregulin-2; TPEFtomoregulin; TR-2; transmembrane protein TENB2; transmembrane protein with EGF-like and two follistatin-like domains 2; Transmembrane protein with EGF-like and two follistatin-like domains; TRtomoregulin-2
Molecular Weight
Mass (kDA):
41.428 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q32.3 |
| Sequence: | 2; NC_000002.12 (191948300..192194933, complement) |
Tissue Specificity
Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of normal colonic mucosa. Expressed in prostate carcinoma. Down-regulated in colorectal cancer. Present in Alzheimer disease plaques (at protein level). Isoform 3 is expressed weakly in testis and at high levels in normal and cancerous prostate.
Subcellular Localizations
[Isoform 1]: Membrane; Single-pass type I membrane protein.; [Isoform 2]: Membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Colorectal Cancer
- Malignant Neoplasm Of Prostate
- Adenocarcinoma
- Colorectal Neoplasms
- Prostatic Neoplasms
- Hyperplasia
- Adenoma
- Neoplasm Metastasis
- Carcinogenesis
Interacting Proteins
- APP
Pathways
- Methylation
- Dna Methylation
- Gene Silencing
- Cell Proliferation
- Mismatch Repair
- Dna Hypermethylation
- Dna Hypomethylation
- Reverse Transcription
- Pathogenesis
- Induction Of Apoptosis
- Proteolysis
- Fibroblast Proliferation
- Limb Development
PTMs
- Methylation
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TMEFF2
bosterbio.com/bosterbio-gene-info-cards/TMEFF2
References
PMID: 10903839 by Horie M., et al. Identification and characterization of TMEFF2, a novel survival factor for hippocampal and mesencephalic neurons.
PMID: 10987305 by Liang G., et al. The gene for a novel transmembrane protein containing epidermal growth factor and follistatin domains is frequently hypermethylated in human tumor cells.