Tropomodulin-4 Antibodies

AND TMOD4 ELISA kits, Tropomodulin-4 Proteins

Many biological assays use antibodies to detect Tropomodulin-4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Tropomodulin-4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Tropomodulin-4 antibodies...

We validate the specificity of these antibodies to Tropomodulin-4 by testing them on tissues known to express TMOD4 positively and negatively. Browse below to find the TMOD4 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TMOD4 Infographic by Boster Bio

All TMOD4 Products

Product

Figures

Specificity

Applications

Price

Anti-Tropomodulin-4 TMOD4 Antibody

Human, Mouse, Rat

$405
Cat # A10885
100ul

Tropomodulin 4 (TMOD4) (NM_013353) Human Over-expression Lysate

Human

$628
Cat # LS029765
100 µg

TMOD4 Overview

Facts about Tropomodulin-4.

TMOD4 3D structure. Source: alphafold

Tropomodulin-4 (TMOD4)

Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the brief actin protofilament, which in turn defines the geometry of the membrane skeleton.

Gene Information

Human
Gene Name:	TMOD4
Uniprot:	Q9NZQ9
Entrez:	29765

Family

Belongs to:

tropomodulin family

Alternative Names

actin-capping protein; DKFZp779I0852; Skeletal muscle tropomodulin; SK-TMOD; tropomodulin 4 (muscle); tropomodulin-4

Molecular Weight

Mass (kDA):
39.335 kDA

Genomic Context


Human

Location:	1q21.3
Sequence:	1; NC_000001.11 (151169986..151175981, complement)

Tissue Specificity

Highly expressed in skeletal muscle.

Subcellular Localizations

Cytoplasm, cytoskeleton. In myofibrils with sarcomeric structure, localizes to the pointed end of actin thin filaments (PubMed:25250574).

Diseases

Sclerosis
Primary Lateral Sclerosis
Amyotrophic Lateral Sclerosis
Hypertrophic Cardiomyopathy
Muscular Atrophy
Atrophy
Tissue Adhesions
Dystrophy
Misalignment
Cardiomyopathies

Hypertrophy
Wiskott-aldrich Syndrome
Muscular Dystrophies, Limb-girdle
Muscular Dystrophy

Pathways

Muscle Contraction
Reverse Transcription
Myofibril Assembly
Hatching
Cell Fate Determination
Muscle Atrophy

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TMOD4

References

PMID: 10497209 by Almenar-Queralt A., et al. Identification of a novel tropomodulin isoform, skeletal tropomodulin, that caps actin filament pointed ends in fast skeletal muscle.

PMID: 10662549 by Cox P.R., et al. Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs.