TPCN1 Antibodies

AND TPCN1 ELISA kits, TPCN1 Proteins

Many biological assays use antibodies to detect TPCN1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TPCN1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TPCN1 antibodies...

We validate the specificity of these antibodies to TPCN1 by testing them on tissues known to express TPCN1 positively and negatively. Browse below to find the TPCN1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TPCN1 Infographic by Boster Bio

All TPCN1 Products

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TPCN1 (NM_001143819) Human Over-expression Lysate

Human

$960
Cat # LS053373
20 µg, 100 µg

TPCN1 Overview

Facts about Two pore calcium channel protein 1.

TPCN1 3D structure. Source: alphafold

Two pore calcium channel protein 1 (TPCN1)

Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the significant voltage-gated Ca(2+) channels (VDCC) across the lysosomal and endosomal membrane. .

Gene Information

Human
Gene Name:	TPCN1
Uniprot:	Q9ULQ1
Entrez:	53373

Family

Belongs to:

calcium channel alpha-1 subunit (TC 1.A.1.11) family

Alternative Names

FLJ20612; KIAA1169; TPC1; two pore segment channel 1; two-pore channel 1; two-pore segment channel 1; voltage-dependent calcium channel protein TPC1

Molecular Weight

Mass (kDA):
94.147 kDA

Genomic Context


Human

Location:	12q24.13
Sequence:	12; NC_000012.12 (113221429..113298589)

Tissue Specificity

Highest expression found in the heart and kidney, and lowest expression found in the spleen.

Subcellular Localizations

Lysosome membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein.

Diseases

Myeloproliferative Syndrome, Transient
Cardiomyopathies
Heart Failure
Cardiomyopathy, Familial Idiopathic
Diabetes Mellitus
Von Willebrand Disease

Interacting Proteins

HAX1
TPCN2

Pathways

Transport
Cell Activation
Intracellular Transport
Smooth Muscle Contraction
Endothelial Cell Activation
Response To Cold
Glycosylation
Muscle Contraction

Localization
Secretion

PTMs

Biotinylation

Oxidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TPCN1

References

PMID: 19387438 by Calcraft P.J., et al. NAADP mobilizes calcium from acidic organelles through two-pore channels.

PMID: 19620632 by Brailoiu E., et al. Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling.