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- Table of Contents
Facts about T cell receptor alpha variable 17.
Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.
Human | |
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Gene Name: | TRAV17 |
Uniprot: | A0A0B4J275 |
Entrez: | 28666 |
Belongs to: |
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No superfamily |
T cell receptor alpha variable 17
Mass (kDA):
12.5 kDA
Human | |
---|---|
Location: | 14q11.2 |
Sequence: | 14; NC_000014.9 (21997686..21998168) |
Cell membrane.
PMID: 12508121 by Heilig R., et al. The DNA sequence and analysis of human chromosome 14.
PMID: 15040585 by Nikolich-Zugich J., et al. The many important facets of T-cell repertoire diversity.