TRAV21 Antibodies

AND TRAV21 ELISA kits, TRAV21 Proteins

Many biological assays use antibodies to detect TRAV21, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRAV21 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRAV21 antibodies...

We validate the specificity of these antibodies to TRAV21 by testing them on tissues known to express TRAV21 positively and negatively. Browse below to find the TRAV21 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TRAV21 Infographic by Boster Bio

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TRAV21 Overview

Facts about T cell receptor alpha variable 21.

TRAV21 3D structure. Source: alphafold

T cell receptor alpha variable 21 (TRAV21)

V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.

Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.

Gene Information

Human
Gene Name:	TRAV21
Uniprot:	A0A0B4J279
Entrez:	28662

Family

Belongs to:

No superfamily

Alternative Names

T cell receptor alpha variable 21

Molecular Weight

Mass (kDA):
12.289 kDA

Genomic Context


Human

Location:	14q11.2
Sequence:	14; NC_000014.9 (22052521..22053056)

Subcellular Localizations

Cell membrane.

PTMs

Disulfide bond

Glycoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRAV21

References

PMID: 15837811 by Chen J.-L., et al. Structural and kinetic basis for heightened immunogenicity of T cell vaccines.

PMID: 26917722 by Bianchi V., et al. A Molecular Switch Abrogates Glycoprotein 100 (gp100) T-cell Receptor (TCR) Targeting of a Human Melanoma Antigen.