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- Table of Contents
Facts about T cell receptor alpha variable 21.
Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.
Human | |
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Gene Name: | TRAV21 |
Uniprot: | A0A0B4J279 |
Entrez: | 28662 |
Belongs to: |
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No superfamily |
T cell receptor alpha variable 21
Mass (kDA):
12.289 kDA
Human | |
---|---|
Location: | 14q11.2 |
Sequence: | 14; NC_000014.9 (22052521..22053056) |
Cell membrane.
PMID: 15837811 by Chen J.-L., et al. Structural and kinetic basis for heightened immunogenicity of T cell vaccines.
PMID: 26917722 by Bianchi V., et al. A Molecular Switch Abrogates Glycoprotein 100 (gp100) T-cell Receptor (TCR) Targeting of a Human Melanoma Antigen.