TRAV22 Antibodies

AND TRAV22 ELISA kits, TRAV22 Proteins

Many biological assays use antibodies to detect TRAV22, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRAV22 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRAV22 antibodies...

We validate the specificity of these antibodies to TRAV22 by testing them on tissues known to express TRAV22 positively and negatively. Browse below to find the TRAV22 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TRAV22 Infographic by Boster Bio

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TRAV22 Overview

Facts about T cell receptor alpha variable 22.

TRAV22 3D structure. Source: alphafold

T cell receptor alpha variable 22 (TRAV22)

V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.

Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.

Gene Information

Human
Gene Name:	TRAV22
Uniprot:	A0A0B4J277
Entrez:	28661

Family

Belongs to:

No superfamily

Alternative Names

T cell receptor alpha variable 22

Molecular Weight

Mass (kDA):
12.145 kDA

Genomic Context


Human

Location:	14q11.2
Sequence:	14; NC_000014.9 (22070690..22071208)

Subcellular Localizations

Cell membrane.

PTMs

Disulfide bond

Glycoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRAV22

References

PMID: 26147596 by Rodstrom K.E., et al. Structure of Staphylococcal Enterotoxin E in Complex with TCR Defines the Role of TCR Loop Positioning in Superantigen Recognition.

PMID: 27180909 by Rodstrom K.E., et al. Two common structural motifs for TCR recognition by staphylococcal enterotoxins.