TRAV27 Antibodies

AND TRAV27 ELISA kits, TRAV27 Proteins

Many biological assays use antibodies to detect TRAV27, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRAV27 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRAV27 antibodies...

We validate the specificity of these antibodies to TRAV27 by testing them on tissues known to express TRAV27 positively and negatively. Browse below to find the TRAV27 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TRAV27 Infographic by Boster Bio

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TRAV27 Overview

Facts about T cell receptor alpha variable 27.

TRAV27 3D structure. Source: alphafold

T cell receptor alpha variable 27 (TRAV27)

V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.

Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.

Gene Information

Human
Gene Name:	TRAV27
Uniprot:	A0A087WT01
Entrez:	28655

Family

Belongs to:

No superfamily

Alternative Names

T cell receptor alpha variable 27

Molecular Weight

Mass (kDA):
12.043 kDA

Genomic Context


Human

Location:	14q11.2
Sequence:	14; NC_000014.9 (22148092..22148633)

Subcellular Localizations

Cell membrane.

PTMs

Disulfide bond

Glycoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRAV27

References

PMID: 21081917 by Saline M., et al. The structure of superantigen complexed with TCR and MHC reveals novel insights into superantigenic T cell activation.

PMID: 27036003 by Valkenburg S.A., et al. Molecular basis for universal HLA-A*0201-restricted CD8+ T-cell immunity against influenza viruses.