TRAV8-4 Antibodies

AND TRAV8-4 ELISA kits, TRAV8-4 Proteins

Many biological assays use antibodies to detect TRAV8-4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRAV8-4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRAV8-4 antibodies...

We validate the specificity of these antibodies to TRAV8-4 by testing them on tissues known to express TRAV8-4 positively and negatively. Browse below to find the TRAV8-4 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: SEPTIN9 Next: IGLV1-51

TRAV8-4 Infographic by Boster Bio

All TRAV8-4 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

TRAV8-4 Overview

Facts about T cell receptor alpha variable 8-4.

TRAV8-4 3D structure. Source: alphafold

T cell receptor alpha variable 8-4 (TRAV8-4)

V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.

Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR into pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 allowing the recruitment of ZAP70.

Gene Information

Human
Gene Name:	TRAV8-4
Uniprot:	P01737
Entrez:	28682

Family

Belongs to:

No superfamily

Alternative Names

T cell receptor alpha variable 8-4

Molecular Weight

Mass (kDA):
12.377 kDA

Genomic Context


Human

Location:	14q11.2
Sequence:	14; NC_000014.9 (21894561..21895030)

Subcellular Localizations

Cell membrane.

PTMs

Disulfide bond

Glycoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRAV8-4

References

PMID: 3873654 by Yanagi Y., et al. Analysis of cDNA clones specific for human T cells and the alpha and beta chains of the T-cell receptor heterodimer from a human T-cell line.