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- Table of Contents
Facts about T cell receptor beta variable 11-2.
Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.
Human | |
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Gene Name: | TRBV11-2 |
Uniprot: | A0A584 |
Entrez: | 28581 |
Belongs to: |
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No superfamily |
T cell receptor beta variable 11-2
Mass (kDA):
12.743 kDA
Human | |
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Location: | 7q34 |
Sequence: | 7; NC_000007.14 (142433956..142434394) |
Cell membrane.
PMID: 8650574 by Rowen L., et al. The complete 685-kilobase DNA sequence of the human beta T cell receptor locus.