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- Table of Contents
Facts about T cell receptor beta variable 12-3.
Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.
Human | |
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Gene Name: | TRBV12-3 |
Uniprot: | P01733 |
Entrez: | 28577 |
Belongs to: |
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No superfamily |
T cell receptor beta variable 12-3
Mass (kDA):
12.997 kDA
Human | |
---|---|
Location: | 7q34 |
Sequence: | 7; NC_000007.14 (142560485..142560931) |
Cell membrane.
PMID: 6336315 by Yanagi Y., et al. A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains.
PMID: 3866244 by Toyonaga B., et al. Organization and sequences of the diversity, joining, and constant region genes of the human T-cell receptor beta chain.