TRBV19 Antibodies

AND TRBV19 ELISA kits, TRBV19 Proteins

Many biological assays use antibodies to detect TRBV19, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRBV19 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRBV19 antibodies...

We validate the specificity of these antibodies to TRBV19 by testing them on tissues known to express TRBV19 positively and negatively. Browse below to find the TRBV19 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TRBV19 Infographic by Boster Bio

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TRBV19 Overview

Facts about T cell receptor beta variable 19.

TRBV19 3D structure. Source: alphafold

T cell receptor beta variable 19 (TRBV19)

V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.

Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.

Gene Information

Human
Gene Name:	TRBV19
Uniprot:	A0A075B6N1
Entrez:	28568

Family

Belongs to:

No superfamily

Alternative Names

T cell receptor beta variable 19

Molecular Weight

Mass (kDA):
12.769 kDA

Genomic Context


Human

Location:	7q34
Sequence:	7; NC_000007.14 (142619057..142619532)

Subcellular Localizations

Cell membrane.

PTMs

Disulfide bond

Glycoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRBV19

References

PMID: 25015819 by Rodstrom K.E., et al. Structure of the superantigen staphylococcal enterotoxin B in complex with TCR and peptide-MHC demonstrates absence of TCR-peptide contacts.

PMID: 27036003 by Valkenburg S.A., et al. Molecular basis for universal HLA-A*0201-restricted CD8+ T-cell immunity against influenza viruses.