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- Table of Contents

Facts about T cell receptor beta variable 6-1.
Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.
| Human | |
|---|---|
| Gene Name: | TRBV6-1 |
| Uniprot: | A0A0K0K1D8 |
| Entrez: | 28606 |

| Belongs to: |
|---|
| No superfamily |

T cell receptor beta variable 6-1
Mass (kDA):
12.632 kDA

| Human | |
|---|---|
| Location: | 7q34 |
| Sequence: | 7; NC_000007.14 (142328354..142328786) |
Cell membrane.


PMID: 12853948 by Hillier L.W., et al. The DNA sequence of human chromosome 7.
PMID: 15040585 by Nikolich-Zugich J., et al. The many important facets of T-cell repertoire diversity.