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- Table of Contents
Facts about T cell receptor beta variable 6-5.
Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.
Human | |
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Gene Name: | TRBV6-5 |
Uniprot: | A0A0K0K1A5 |
Entrez: | 28602 |
Belongs to: |
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No superfamily |
T cell receptor beta variable 6-5
Mass (kDA):
12.402 kDA
Human | |
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Location: | 7q34 |
Sequence: | 7; NC_000007.14 (142451013..142451448) |
Cell membrane.
PMID: 8906788 by Garboczi D.N., et al. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2.
PMID: 9586631 by Ding Y.H., et al. Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids.