TRBV7-9 Antibodies

AND TRBV7-9 ELISA kits, TRBV7-9 Proteins

Many biological assays use antibodies to detect TRBV7-9, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRBV7-9 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRBV7-9 antibodies...

We validate the specificity of these antibodies to TRBV7-9 by testing them on tissues known to express TRBV7-9 positively and negatively. Browse below to find the TRBV7-9 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TRBV7-9 Infographic by Boster Bio

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TRBV7-9 Overview

Facts about T cell receptor beta variable 7-9.

TRBV7-9 3D structure. Source: alphafold

T cell receptor beta variable 7-9 (TRBV7-9)

V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.

Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.

Gene Information

Human
Gene Name:	TRBV7-9
Uniprot:	P04435
Entrez:	28589

Family

Belongs to:

No superfamily

Alternative Names

T cell receptor beta variable 7-9

Molecular Weight

Mass (kDA):
13.107 kDA

Genomic Context


Human

Location:	7q34
Sequence:	7; NC_000007.14 (142529290..142529762)

Subcellular Localizations

Cell membrane.

PTMs

Disulfide bond

Glycoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRBV7-9

References

PMID: 2426193 by Leiden J.M., et al. The complete primary structure of the T-cell receptor genes from an alloreactive cytotoxic human T-lymphocyte clone.

PMID: 24194959 by Hedlund G., et al. The tumor targeted superantigen ABR-217620 selectively engages TRBV7- 9 and exploits TCR-pMHC affinity mimicry in mediating T cell cytotoxicity.