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- Table of Contents
Facts about T cell receptor delta variable 3.
Binding of gamma-delta TR complicated to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains from the LCK and FYN kinases, permitting the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, leading to calcium mobilization and ERK activation, ultimately resulting in T cell expansion and differentiation into effector cells (PubMed:25674089).
Human | |
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Gene Name: | TRDV3 |
Uniprot: | A0JD37 |
Entrez: | 28516 |
Belongs to: |
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No superfamily |
T cell receptor delta variable 3
Mass (kDA):
12.981 kDA
Human | |
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Location: | 14q11.2 |
Sequence: | 14; NC_000014.9 (22469041..22469614, complement) |
Cell membrane.
PMID: 9110172 by Boysen C., et al. Analysis of the 1.1-Mb human alpha/delta T-cell receptor locus with bacterial artificial chromosome clones.
PMID: 23348415 by Vantourout P., et al. Six-of-the-best: unique contributions of gammadelta T cells to immunology.