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- Table of Contents
TRIM58 Antibodies
AND TRIM58 ELISA kits, TRIM58 Proteins
Many biological assays use antibodies to detect TRIM58, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRIM58 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRIM58 antibodies...
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TRIM58 Overview
Facts about E3 ubiquitin-protein ligase TRIM58.
E3 ubiquitin-protein ligase TRIM58 (TRIM58)
E3 ubiquitin ligase triggered during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complicated.
May participate in the erythroblast enucleation procedure through regulation of nuclear polarization. .
Gene Information
| Human | |
|---|---|
| Gene Name: | TRIM58 |
| Uniprot: | Q8NG06 |
| Entrez: | 25893 |
Family
| Belongs to: |
|---|
| TRIM/RBCC family |
Alternative Names
BIA2; DKFZp434C091; Protein BIA2; tripartite motif containing 58; tripartite motif-containing 58; tripartite motif-containing protein 58
Molecular Weight
Mass (kDA):
54.766 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q44 |
| Sequence: | 1; NC_000001.11 (247857187..247880138) |
Tissue Specificity
Expressed in erythroblasts.
Diseases
- Cell Transformation, Neoplastic
- Liver Carcinoma
- Hepatitis
- Liver Neoplasms
- Hepatitis B
- Carcinoma
Pathways
- Methylation
- Aging
PTMs
Research Areas
- Zinc Finger
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRIM58
bosterbio.com/bosterbio-gene-info-cards/TRIM58
References
PMID: 25241935 by Thom C.S., et al. Trim58 degrades Dynein and regulates terminal erythropoiesis.