TRPC4AP Antibodies

AND TRPC4AP ELISA kits, TRPC4AP Proteins

Many biological assays use antibodies to detect TRPC4AP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRPC4AP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRPC4AP antibodies...

We validate the specificity of these antibodies to TRPC4AP by testing them on tissues known to express TRPC4AP positively and negatively. Browse below to find the TRPC4AP antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TRPC4AP Infographic by Boster Bio

All TRPC4AP Products

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Specificity

Applications

Price

TRPC4AP (NM_015638) Human Over-expression Lysate

Human

$628
Cat # LS026133
20 µg, 100 µg

Anti-TRPC4AP antibody

Human

ELISA, IP, WB

$370
Cat # A09945-2
100 μl/vial

TRPC4AP Overview

Facts about Short transient receptor potential channel 4-associated protein.

TRPC4AP 3D structure. Source: alphafold

Short transient receptor potential channel 4-associated protein (TRPC4AP)

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC.

Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2.

Gene Information

Human
Gene Name:	TRPC4AP
Uniprot:	Q8TEL6
Entrez:	26133

Family

Belongs to:

No superfamily

Alternative Names

C20orf188; dJ756N5.2; DKFZp586C1223; DKFZP727M231; Protein TAP1; Protein TRUSS; short transient receptor potential channel 4 associated protein; short transient receptor potential channel 4-associated protein; TNF-receptor ubiquitous scaffolding/signaling protein; transient receptor potential cation channel, subfamily C, member 4 associatedprotein; Trp4-associated protein; Trpc4-associated protein; TRRP4APchromosome 20 open reading frame 188; TRUSS; tumor necrosis factor receptor-associated ubiquitous scaffolding and signalingprotein

Molecular Weight

Mass (kDA):
90.852 kDA

Genomic Context


Human

Location:	20q11.22
Sequence:	20; NC_000020.11 (35002404..35092835, complement)

Diseases

Alzheimer's Disease
Malignant Neoplasms
Neoplasms
Neurodegenerative Disorders
Hallucinations
Impaired Cognition

Interacting Proteins

PPP1CA

Pathways

Protein Stabilization

PTMs

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRPC4AP

References

PMID: 20551172 by Choi S.H., et al. Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells.

PMID: 19966799 by Li T., et al. A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery.