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- Table of Contents
TSG101 Antibodies
AND TSG101 ELISA kits, TSG101 Proteins
Many biological assays use antibodies to detect TSG101, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TSG101 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TSG101 antibodies...
Designing a Western blot for TSG101? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the TSG101 Western Blot GuideDesigning an IHC experiment for TSG101? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the TSG101 IHC GuideTSG101 Infographic by Boster Bio
All TSG101 Products
Product
Figures
Specificity
Applications
Price
Anti-TSG101 Antibody Picoband®
6 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IP, WB
$370
Cat # A01233-2
100 μg/vial
Cat # A01233-2
100 μg/vial
Anti-TSG101 Rabbit Monoclonal Antibody
10 Citations
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01233
100 μl
Cat # M01233
100 μl
Human, Mouse, Rat
ELISA, IP, IF, WB
$146
Cat # M01233-2
20μL, 40μL, 100μL, 200μL
Cat # M01233-2
20μL, 40μL, 100μL, 200μL
TSG101 Overview
Facts about Tumor susceptibility gene 101 protein.
Tumor susceptibility gene 101 protein (TSG101)
Part of the ESCRT-I complicated, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs).
Mediates the association between the ESCRT-0 and ESCRT-I complicated. Required for completion of cytokinesis; the function requires CEP55.
Gene Information
| Human | |
|---|---|
| Gene Name: | TSG101 |
| Uniprot: | Q99816 |
| Entrez: | 7251 |
Family
| Belongs to: |
|---|
| ubiquitin-conjugating enzyme family |
Alternative Names
ESCRT-I complex subunit TSG101; TSG10; tumor susceptibility gene 10; tumor susceptibility gene 101 protein; tumor susceptibility gene 101; tumor susceptibility protein; VPS23
Molecular Weight
Mass (kDA):
43.944 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11p15.1 |
| Sequence: | 11; NC_000011.10 (18480311..18526942, complement) |
Tissue Specificity
Heart, brain, placenta, lung, liver, skeletal, kidney and pancreas.
Subcellular Localizations
Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Late endosome membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody, Midbody ring. Nucleus. Mainly cytoplasmic. Membrane-associated when active and soluble when inactive. Nuclear localization is cell cycle-dependent. Interaction with CEP55 is required for localization to the midbody during cytokinesis.
Diseases
- Neoplasms
- Hiv Infections
- Malignant Neoplasms
- Immunologic Deficiency Syndromes
- Malignant Neoplasm Of Breast
- Cell Transformation, Neoplastic
- Mammary Neoplasms
- Leukemia
- Carcinoma
- Metaplastic Cell Transformation
- Carcinogenesis
- Neoplasm Metastasis
Interacting Proteins
- BAG4
- CD2AP
- CEP55
- DAXX
- FAM9B
- HAUS1
- HGS
- Hgs
- IQGAP1
- KIFC3
Pathways
- Transport
- Localization
- Cell Cycle
- Cytokinesis
- Pathogenesis
- Endocytosis
- Abscission
- Cell Growth
- Cell Proliferation
- Cell Death
- Viral Replication
- Cell Division
- Reverse Transcription
PTMs
- Ubiquitination
- Phosphorylation
- Cleavage
- Glycosylation
- Methylation
- Sumoylation
Research Areas
- Autophagy
- Microautophagy
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TSG101
bosterbio.com/bosterbio-gene-info-cards/TSG101
References
PMID: 9019400 by Li L., et al. The TSG101 tumor susceptibility gene is located in chromosome 11 band p15 and is mutated in human breast cancer.
PMID: 9366528 by Gayther S.A., et al. Aberrant splicing of the TSG101 and FHIT genes occurs frequently in multiple malignancies and in normal tissues and mimics alterations previously described in tumours.
2 Publications of Boster TSG101 Antibodies & ELISA Kits
- PubMed ID: 32258168, Tian F,Tang P,Sun Z,Zhang R,Zhu D,He J,Liao J,Wan Q,Shen J.miR-210 in Exosomes D...
- PubMed ID: -, Pei-pei Fang,Chen-wei Pan,Wei Lin,Jie Li,Shan-shan Huang,Guang-yao Zhou,Wen-jun ...
*More publications can be found for each product on its corresponding product page