TSG101 Antibodies

Tumor susceptibility gene 101 protein (TSG101)

Part of the ESCRT-I complicated, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs).

Mediates the association between the ESCRT-0 and ESCRT-I complicated. Required for completion of cytokinesis; the function requires CEP55.

Gene Information

Human
Gene Name:	TSG101
Uniprot:	Q99816
Entrez:	7251

Family

Belongs to:
ubiquitin-conjugating enzyme family

Alternative Names

ESCRT-I complex subunit TSG101; TSG10; tumor susceptibility gene 10; tumor susceptibility gene 101 protein; tumor susceptibility gene 101; tumor susceptibility protein; VPS23

Molecular Weight

Mass (kDA):
43.944 kDA

Genomic Context

Human
Location:	11p15.1
Sequence:	11; NC_000011.10 (18480311..18526942, complement)

Tissue Specificity

Heart, brain, placenta, lung, liver, skeletal, kidney and pancreas.

Subcellular Localizations

Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Late endosome membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody, Midbody ring. Nucleus. Mainly cytoplasmic. Membrane-associated when active and soluble when inactive. Nuclear localization is cell cycle-dependent. Interaction with CEP55 is required for localization to the midbody during cytokinesis.

Diseases

• Neoplasms
• Hiv Infections
• Malignant Neoplasms
• Immunologic Deficiency Syndromes
• Malignant Neoplasm Of Breast
• Cell Transformation, Neoplastic
• Mammary Neoplasms
• Leukemia
• Carcinoma
• Metaplastic Cell Transformation
• Carcinogenesis
• Neoplasm Metastasis

• Anemia
• Acquired Immunodeficiency Syndrome
• Equine Infectious Anemia
• Ovarian Neoplasm
• Sarcoma
• Adenocarcinoma
• Malignant Paraganglionic Neoplasm

Interacting Proteins

• BAG4
• CD2AP
• CEP55
• DAXX
• FAM9B

• HAUS1
• HGS
• Hgs
• IQGAP1
• KIFC3

• KRT18
• KRT31
• LITAF
• LRSAM1
• MGRN1

• PDLIM7
• PTPN23
• ROCK1
• SYCE1
• TAX1BP1

• USHBP1
• VPS28
• VPS37A
• VPS37C

Pathways

• Transport
• Localization
• Cell Cycle
• Cytokinesis
• Pathogenesis
• Endocytosis
• Abscission
• Cell Growth
• Cell Proliferation
• Cell Death
• Viral Replication
• Cell Division
• Reverse Transcription

• Translation
• Rna Interference
• Secretion
• Oncogenesis
• S Phase
• Proteolysis
• Cell Cycle Arrest

PTMs

• Ubiquitination
• Phosphorylation
• Cleavage
• Glycosylation
• Methylation
• Sumoylation

• Isgylation
• Farnesylation
• Deacetylation
• Dephosphorylation
• Geranylgeranylation
• Ribosylation

Research Areas

• Autophagy
• Microautophagy

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TSG101

Boster Bio: Best Uses Of The TSG101 Marker

You're probably curious to learn more about the Boster Bio: Anti TSG101 Marker. It has been utilized in ICC, WB, and IF and is able to react with Human TSG101. But are there other applications for this antibody? Read on to find out. This article will help you discover the best applications for this anti-TSG101. This article also includes useful tips and details to make your experience with this product more enjoyable.

Boster Bio: Anti-TSG101 Marker

Antibodies to the TSG101 protein are available from a range of suppliers. The antigen is expressed as a protein . It is also known by its common names TSG101 or VPS23. The protein itself is quite heavy, at 43.9 kilograms. In addition to human, mouse and rat species have orthologs of this protein. Boster Bio creates antibodies against TSG101.

The incubation of primary antibodies is done overnight at 4°C. Primary antibodies included boster bio PB0981, anti Alix, and anti-TSG101. Secondary antibodies were added and incubated for 1 h at ambient temperature. Then, the immunoreactive Blots were visualized using either a ChemiDocXRS or Prolight HRP chemical luminescence kit.

Boster Bio: TSG101 Marker

There are many sources of antibodies for TSG101. Boster Bio has a TSG101 specific antibody that has been tested for use in flow cytometry, IF, and ICC. The antibody is able to be kept at -20°C for one year and then frozen for six months. It also has the ability to react with both Human and Rat. The antibody is made up of 5 mg of BSA. You can also purchase an anti-blocking peptide that is highly reactive to Human TSG101 to get more information.