TTLL5 Antibodies

AND TTLL5 ELISA kits, TTLL5 Proteins

Many biological assays use antibodies to detect TTLL5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TTLL5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TTLL5 antibodies...

We validate the specificity of these antibodies to TTLL5 by testing them on tissues known to express TTLL5 positively and negatively. Browse below to find the TTLL5 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TTLL5 Infographic by Boster Bio

All TTLL5 Products

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Anti-TTLL5 Antibody Picoband®

Western blot analysis of TTLL5 using anti-TTLL5 antibody (A09637-1)

Human

ELISA, WB

$370
Cat # A09637-1
100 μg/vial

TTLL5 Overview

Facts about Tubulin polyglutamylase TTLL5.

TTLL5 3D structure. Source: alphafold

Tubulin polyglutamylase TTLL5 (TTLL5)

Polyglutamylase which preferentially modifies alpha- tubulin. Involved from the side-chain initiation step of the polyglutamylation response rather than from the elongation step (By similarity).

Needed for CCSAP localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction (PubMed:17116691, PubMed:22493317).

Gene Information

Human
Gene Name:	TTLL5
Uniprot:	Q6EMB2
Entrez:	23093

Family

Belongs to:

tubulin--tyrosine ligase family

Alternative Names

STAMP; tubulin tyrosine ligase-like family, member 5

Molecular Weight

Mass (kDA):
143.577 kDA

Genomic Context


Human

Location:	14q24.3
Sequence:	14; NC_000014.9 (75661246..75955079)

Tissue Specificity

Expressed in the retina, found in the rod and cone photoreceptors (at protein level). Widely expressed with highest levels in heart and skeletal muscle and low levels in other tissues.

Subcellular Localizations

Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Nucleus. Cytoplasm. Localized to the base of the connecting cilium between the basal body and the adjacent daughter centriole of the cilium. In osteosarcoma cells, found in both cytoplasm and nucleus in the absence of steroid but located exclusively in the nucleus in the presence of steroid.

Diseases

Cell Transformation, Neoplastic
Malignant Neoplasms
Pancreatic Acinar Atrophy
Traditional Serrated Adenoma
Endometrial Carcinoma
Malignant Neoplasm Of Ovary
Endometrial Polyp

Malignant Paraganglionic Neoplasm
Ovarian Neoplasm

Pathways

Nucleosome Assembly
Histone Deacetylation
Cell Growth

PTMs

Phosphorylation

Deacetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TTLL5

References

PMID: 17116691 by He Y., et al. STAMP, a novel predicted factor assisting TIF2 actions in glucocorticoid receptor-mediated induction and repression.

PMID: 22493317 by Backer C.B., et al. CSAP localizes to polyglutamylated microtubules and promotes proper cilia function and zebrafish development.