TYK2 Antibodies

AND TYK2 ELISA kits, TYK2 Proteins

Many biological assays use antibodies to detect TYK2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TYK2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TYK2 antibodies...

We validate the specificity of these antibodies to TYK2 by testing them on tissues known to express TYK2 positively and negatively. Browse below to find the TYK2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for TYK2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the TYK2 Western Blot Guide

TYK2 Infographic by Boster Bio

All TYK2 Products

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Specificity

Applications

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Anti-TYK2 Antibody Picoband®

Western blot analysis of TYK2 using anti-TYK2 antibody (A01642-3)

Flow Cytometry analysis of MCF-7 cells using anti-TYK2 antibody (A01642-3)

Human

ELISA, Flow Cytometry, WB

$370
Cat # A01642-3
100 μg/vial

Anti-TYK2 Antibody

Western blot analysis of TYK2 in human small intestine tissue lysate with TYK2 antibody at (A) 1 and (B) 2 μg/mL

Immunofluorescence of TYK2 in A549 cells with TYK2 Antibody at 20 μg/ml

Human, Mouse, Rat

ELISA, IF, WB

$481
Cat # A01642-1
0.1 mg

TYK2 Overview

Facts about Non-receptor tyrosine-protein kinase TYK2.

TYK2 3D structure. Source: alphafold

Non-receptor tyrosine-protein kinase TYK2 (TYK2)

Probably involved in intracellular signal transduction by being involved from the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.

Gene Information

Human
Gene Name:	TYK2
Uniprot:	P29597
Entrez:	7297

Family

Belongs to:

protein kinase superfamily

Alternative Names

EC 2.7.10; EC 2.7.10.2; JTK1; non-receptor tyrosine-protein kinase TYK2; Tyk2; tyrosine kinase 2

Molecular Weight

Mass (kDA):
133.65 kDA

Genomic Context


Human

Location:	19p13.2
Sequence:	19; NC_000019.10 (10350528..10380572, complement)

Tissue Specificity

Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.

Diseases

Janiceps
Leukemia
Malignant Neoplasms
Neoplasms
Inflammation
Autoimmune Reaction
Virus Diseases
Infective Disorder
Carcinoma
Immunologic Deficiency Syndromes
Autoimmune Diseases
Lupus Erythematosus, Systemic
Job's Syndrome

Liver Carcinoma
Hepatitis
Multiple Sclerosis
Arthritis
Myeloid Leukemia
Sclerosis
Lymphoma

Interacting Proteins

FHL3
HNRNPK
HSP90AB1
JAK2
KHDRBS2

KRT40
TRAF4

Pathways

Pathogenesis
Cell Growth
Cell Proliferation
Secretion
Immune Response
Localization
Cell Cycle
Intracellular Signal Transduction
Cell Development
Cell Death
Cell Differentiation
T Cell Proliferation
Viral Replication

Platelet Aggregation
Endocytosis
Rna Interference
Cell Migration
Oncogenesis
Hypersensitivity
Innate Immune Response

PTMs

Phosphorylation
Dephosphorylation
Ubiquitination
Cleavage
Methylation

Sumoylation
Glycosylation
Acetylation
Demethylation
Glutathionylation

Reduction

Research Areas

Protein Kinase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TYK2

References

PMID: 2216457 by Firmbach-Kraft I., et al. TYK2, prototype of a novel class of non-receptor tyrosine kinase genes.

PMID: 1386289 by Velazquez L., et al. A protein tyrosine kinase in the interferon alpha/beta signaling pathway.