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TYK2 Antibodies
AND TYK2 ELISA kits, TYK2 Proteins
Many biological assays use antibodies to detect TYK2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TYK2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TYK2 antibodies...
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TYK2 Infographic by Boster Bio
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TYK2 Overview
Facts about Non-receptor tyrosine-protein kinase TYK2.
Non-receptor tyrosine-protein kinase TYK2 (TYK2)
Probably involved in intracellular signal transduction by being involved from the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.
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Gene Information
| Human | |
|---|---|
| Gene Name: | TYK2 |
| Uniprot: | P29597 |
| Entrez: | 7297 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.10; EC 2.7.10.2; JTK1; non-receptor tyrosine-protein kinase TYK2; Tyk2; tyrosine kinase 2
Molecular Weight
Mass (kDA):
133.65 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.2 |
| Sequence: | 19; NC_000019.10 (10350528..10380572, complement) |
Tissue Specificity
Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.
Diseases
- Janiceps
- Leukemia
- Malignant Neoplasms
- Neoplasms
- Inflammation
- Autoimmune Reaction
- Virus Diseases
- Infective Disorder
- Carcinoma
- Immunologic Deficiency Syndromes
- Autoimmune Diseases
- Lupus Erythematosus, Systemic
- Job's Syndrome
Interacting Proteins
- FHL3
- HNRNPK
- HSP90AB1
- JAK2
- KHDRBS2
- KRT40
- TRAF4
Pathways
- Pathogenesis
- Cell Growth
- Cell Proliferation
- Secretion
- Immune Response
- Localization
- Cell Cycle
- Intracellular Signal Transduction
- Cell Development
- Cell Death
- Cell Differentiation
- T Cell Proliferation
- Viral Replication
PTMs
- Phosphorylation
- Dephosphorylation
- Ubiquitination
- Cleavage
- Methylation
Research Areas
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TYK2
bosterbio.com/bosterbio-gene-info-cards/TYK2
References
PMID: 2216457 by Firmbach-Kraft I., et al. TYK2, prototype of a novel class of non-receptor tyrosine kinase genes.
PMID: 1386289 by Velazquez L., et al. A protein tyrosine kinase in the interferon alpha/beta signaling pathway.