Timm8a1 Antibodies

AND Timm8a1 ELISA kits, Timm8a1 Proteins

Many biological assays use antibodies to detect Timm8a1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Timm8a1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Timm8a1 antibodies...

We validate the specificity of these antibodies to Timm8a1 by testing them on tissues known to express Timm8a1 positively and negatively. Browse below to find the Timm8a1 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Timm8a1 Infographic by Boster Bio

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Timm8a1 Overview

Facts about Mitochondrial import inner membrane translocase subunit Tim8 A.

Timm8a1 3D structure. Source: alphafold

Mitochondrial import inner membrane translocase subunit Tim8 A (Timm8a1)

Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane.

Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins (By similarity).

Gene Information

Mouse
Gene Name:	Timm8a1
Uniprot:	Q9WVA2
Entrez:	30058

Family

Belongs to:

small Tim family

Alternative Names

Mitochondrial import inner membrane translocase subunit Tim8 A

Molecular Weight

Mass (kDA):
11.042 kDA

Genomic Context


Mouse

Location:	X E3\|X 56.18 cM
Sequence:	X;

Tissue Specificity

Present at high level in liver and brain, and at lower level in muscle and heart. In CNS sections, it is predominantly present in the soma and the dendritic portion of the Purkinje cells of the cerebellum, but not in the glial cells. Scattered expression also is also detected in the brain stem, olfactory bulb, substantia nigra, hippocampus and striatum (at protein level). Ubiquitously expressed.

PTMs

Disulfide bond

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Timm8a1

References

PMID: 10611480 by Bauer M.F., et al. The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom.

PMID: 10873677 by Nakane T., et al. Cloning and expression of mouse deafness dystonia peptide 1 cDNA.