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- Table of Contents
TRIM29 Antibodies
AND TRIM29 ELISA kits, TRIM29 Proteins
Many biological assays use antibodies to detect TRIM29, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRIM29 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRIM29 antibodies...
Designing a Western blot for TRIM29? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the TRIM29 Western Blot GuideTRIM29 Infographic by Boster Bio
All TRIM29 Products
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TRIM29 Overview
Facts about Tripartite motif-containing protein 29.
Tripartite motif-containing protein 29 (TRIM29)
Plays a vital role in the regulation of macrophage activation in response to bacterial or viral infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its'Lys-48' ubiquitination and subsequent degradation.
In turn, the expression of type I interferons and the production of proinflammatory cytokines are inhibited. Additionally, induces the'Lys-48' ubiquitination of TMEM173/STING in a similar manner, resulting in its degradation.
Gene Information
| Human | |
|---|---|
| Gene Name: | TRIM29 |
| Uniprot: | Q14134 |
| Entrez: | 23650 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Ataxia telangiectasia group D-associated protein; ATDC ataxia-telangiectasia group D-associated protein; ATDC; FLJ36085; tripartite motif containing 29; tripartite motif protein TRIM29; tripartite motif-containing 29; tripartite motif-containing protein 29
Molecular Weight
Mass (kDA):
65.835 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q23.3 |
| Sequence: | 11; NC_000011.10 (120111286..120138113, complement) |
Tissue Specificity
Expressed in placenta, prostate and thymus.
Subcellular Localizations
Cytoplasm. Lysosome. Colocalizes with intermediate filaments.
Diseases
- Malignant Neoplasms
- Neoplasms
- Ataxia Telangiectasia
- Carcinoma
- Adenocarcinoma
- Carcinogenesis
- Malignant Squamous Cell Neoplasm
- Neoplasm Metastasis
- Ataxia
- Telangiectasis
- Cell Invasion
- Metastatic Malignant Neoplasm To The Lymph Node
- Malignant Neoplasm Of Breast
Interacting Proteins
- AXIN1
- CARD9
- CEP70
- DVL2
- GCC1
- GOLGA2
- GSK3B
- LZTS2
- MAD1L1
- TRIM23
Pathways
- Cell Cycle
- Cell Proliferation
- Localization
- Pathogenesis
- Programmed Cell Death
- Hypersensitivity
- Menopause
- Keratinocyte Differentiation
- Senescence
- Response To Ionizing Radiation
- Translation
PTMs
- Biotinylation
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRIM29
bosterbio.com/bosterbio-gene-info-cards/TRIM29
References
PMID: 8188213 by Leonhardt E.A., et al. Nucleotide sequence analysis of a candidate gene for ataxia- telangiectasia group D (ATDC).
PMID: 11331580 by Reymond A., et al. The tripartite motif family identifies cell compartments.