UBR4 Antibodies

AND UBR4 ELISA kits, UBR4 Proteins

Many biological assays use antibodies to detect UBR4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with UBR4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop UBR4 antibodies...

We validate the specificity of these antibodies to UBR4 by testing them on tissues known to express UBR4 positively and negatively. Browse below to find the UBR4 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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UBR4 Infographic by Boster Bio

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UBR4 Overview

Facts about E3 ubiquitin-protein ligase UBR4.

E3 ubiquitin-protein ligase UBR4 (UBR4)

E3 ubiquitin-protein ligase which is a part of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing in line with the N-end rule, resulting in their ubiquitination and subsequent degradation.

Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling.

Gene Information

Human
Gene Name:	UBR4
Uniprot:	Q5T4S7
Entrez:	23352

Family

Belongs to:

UBR4 family

Alternative Names

600 kDa retinoblastoma protein-associated factor; EC 6.3.2; EC 6.3.2.-; KIAA0462E3 ubiquitin-protein ligase UBR4; KIAA1307zinc finger, UBR1 type 1; N-recognin-4; p600; RBAF600FLJ41863; Retinoblastoma-associated factor of 600 kDa; ubiquitin protein ligase E3 component n-recognin 4; Zinc finger UBR1-type protein 1; ZUBR1retinoblastoma-associated factor 600-like protein

Molecular Weight

Mass (kDA):
573.841 kDA

Genomic Context


Human

Location:	1p36.13
Sequence:	1; NC_000001.11 (19074508..19214332, complement)

Subcellular Localizations

Membrane; Multi-pass membrane protein. Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Concentrates at the leading edge of membrane structures involved in actin motility.

Diseases

Retinoblastoma
Malignant Neoplasms
Cell Transformation, Neoplastic
Disease Of Adrenal Medulla
Malignant Neoplasm Of Breast
Anosmia
Diabetes Mellitus
Malignant Tumor Of Cervix
Carcinoma
Immunologic Deficiency Syndromes

Neoplasms
Hypertrophy
Hiv Infections
Mammary Neoplasms
Nephrogenic Diabetes Insipidus

Pathways

Proteolysis
Rna Interference

PTMs

Reduction

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/UBR4

References

PMID: 16214886 by Nakatani Y., et al. p600, a unique protein required for membrane morphogenesis and cell survival.

PMID: 16247014 by Lennerz V., et al. The response of autologous T cells to a human melanoma is dominated by mutated neoantigens.