Mitochondrial brown fat uncoupling protein 1 (UCP1)

Mitochondrial protein responsible for thermogenic respiration, a technical capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variants and more generally to the regulation of energy balance (By similarity). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane (PubMed:24196960).

However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons triggered by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat rather than ATP.