Regulator of nonsense transcripts 2 (UPF2)

Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent creation of an UPF1-UPF2-UPF3 surveillance complex (such as UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD.

In collaboration with UPF3B arouses both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA.