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- Table of Contents

Facts about Ubl carboxyl-terminal hydrolase 18.
Necessary to keep a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms. .
| Human | |
|---|---|
| Gene Name: | USP18 |
| Uniprot: | Q9UMW8 |
| Entrez: | 11274 |

| Belongs to: |
|---|
| peptidase C19 family |

EC 3.1.2.15; EC 3.4.19.-; hUBP43; ISG15-specific-processing protease; ISG43; ISG43UBP43; ubiquitin specific peptidase 18; ubiquitin specific protease 18; ubl carboxyl-terminal hydrolase 18; ubl thioesterase 18,43 kDa ISG15-specific protease; Ubl thiolesterase 18; UBP43; USP18
Mass (kDA):
43.011 kDA

| Human | |
|---|---|
| Location: | 22q11.21 |
| Sequence: | 22; NC_000022.11 (18149855..18177397) |
[Isoform 1]: Cytoplasm.; [Isoform 2]: Nucleus. Cytoplasm.






PMID: 10777664 by Schwer H., et al. Cloning and characterization of a novel human ubiquitin-specific protease, a homologue of murine UBP43 (Usp18).
PMID: 11788588 by Malakhov M.P., et al. UBP43 (USP18) specifically removes ISG15 from conjugated proteins.