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UBE2D3 Antibodies
AND UBE2D3 ELISA kits, UBE2D3 Proteins
Many biological assays use antibodies to detect UBE2D3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with UBE2D3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop UBE2D3 antibodies...
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UBE2D3 Infographic by Boster Bio
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UBE2D3 Overview
Facts about Ubiquitin-conjugating enzyme E2 D3.
Ubiquitin-conjugating enzyme E2 D3 (UBE2D3)
Accepts ubiquitin in the E1 complex and catalyzes its covalent attachment to other proteins. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions'Lys-21' or'Lys-22' using a monoubiquitin.
Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA- linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA.
Gene Information
| Human | |
|---|---|
| Gene Name: | UBE2D3 |
| Uniprot: | P61077 |
| Entrez: | 7323 |
Family
| Belongs to: |
|---|
| ubiquitin-conjugating enzyme family |
Alternative Names
E2(17)KB 3; E2(17)KB3; EC 6.3.2.19; MGC43926; MGC5416; UBC4/5; UBC5C; UbcH5c; UBE2D3; Ubiquitin carrier protein D3; ubiquitin-conjugating enzyme E2 D3; Ubiquitin-conjugating enzyme E2(17)KB 3; Ubiquitin-conjugating enzyme E2-17 kDa 3; ubiquitin-conjugating enzyme E2D 3 (homologous to yeast UBC4/5); ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast); Ubiquitin-protein ligase D3
Molecular Weight
Mass (kDA):
16.687 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4q24 |
| Sequence: | 4; NC_000004.12 (102794383..102868893, complement) |
Subcellular Localizations
Cell membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.
Diseases
- Malignant Neoplasms
- Neoplasms
- Acute Promyelocytic Leukemia
- Leukemia
- Leukoencephalopathy, Progressive Multifocal
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Cell Transformation, Neoplastic
- Nephropathy Toxic
- Adenoma
- Neoplasm Metastasis
- Liddle Syndrome
- Neoplasm Invasiveness
Interacting Proteins
- Dapk3
- DTX2
- DTX3
- MID1
- OTUB1
- RNF11
- RNF111
- RNF115
- RNF126
- RNF2
Pathways
- Conjugation
- Cell Death
- Proteolysis
- Endocytosis
- Rna Interference
- Cell Activation
- Programmed Cell Death
- Gene Silencing
- Stem Cell Differentiation
- Regulation Of Signaling
- Aging
- T Cell Activation
- Immune Response
PTMs
- Ubiquitination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/UBE2D3
bosterbio.com/bosterbio-gene-info-cards/UBE2D3
References
PMID: 8530467 by Jensen J.P., et al. Identification of a family of closely related human ubiquitin conjugating enzymes.
PMID: 10329681 by Gonen H., et al. Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha.