Tubulinyl-Tyr carboxypeptidase 1 (VASH1)

Tyrosine carboxypeptidase that eliminates the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146869). Acts as an angiogenesis inhibitor: inhibits migration, proliferation and network formation by endothelial cells in addition to angiogenesis (PubMed:15467828, PubMed:16488400, PubMed:16707096, PubMed:19204325).

This inhibitory effect is selective to endothelial cells as it doesn't affect the migration of smooth muscle cells or fibroblasts (PubMed:15467828, PubMed:16488400, PubMed:16707096). .