Immunoglobulin iota chain Antibodies

AND VPREB1 ELISA kits, Immunoglobulin iota chain Proteins

Many biological assays use antibodies to detect Immunoglobulin iota chain, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Immunoglobulin iota chain in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Immunoglobulin iota chain antibodies...

We validate the specificity of these antibodies to Immunoglobulin iota chain by testing them on tissues known to express VPREB1 positively and negatively. Browse below to find the VPREB1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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VPREB1 Infographic by Boster Bio

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Anti-Immunoglobulin iota chain VPREB1 Antibody

Western blot (WB) analysis of VPREB1 pAb at 1:500 dilution
Lane1:Myla2059 whole cell lysate(40ug)
Lane2:HuT78 whole cell lysate(40ug)
Lane3:K562 whole cell lysate(40ug)

Human

$405
Cat # A10453
100ul

VPREB1 Overview

Facts about Immunoglobulin iota chain.

VPREB1 3D structure. Source: alphafold

Immunoglobulin iota chain (VPREB1)

Associates with the Ig-mu series to form a molecular complex that is expressed on the surface of pre-B-cells. This complicated presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation.

Gene Information

Human
Gene Name:	VPREB1
Uniprot:	P12018
Entrez:	7441

Family

Belongs to:

immunoglobulin superfamily

Alternative Names

CD179 antigen-like family member A; CD179a; IGI; immunoglobulin iota chain; pre-B lymphocyte 1

Molecular Weight

Mass (kDA):
16.605 kDA

Genomic Context


Human

Location:	22q11.22
Sequence:	22; NC_000022.11 (22244786..22245515)

Tissue Specificity

Only expressed by pre-B-cells.

Diseases

Leukemia
Acute Lymphocytic Leukemia
Hypogammaglobulinemia
Neurodegenerative Disorders
X-linked Agammaglobulinemia
Down Syndrome
Leukemia, Myelocytic, Acute
Plasmacytoma
Digeorge Syndrome
Multiple Myeloma
Congenital Heart Defects
Malignant Neoplasms
Myeloid Leukemia

Neoplasms
Lymphopenia
Nervousness
Rheumatoid Arthritis
Infective Disorder
Agammaglobulinemia
B-cell Lymphomas

Pathways

Cell Development
Cell Differentiation
B Cell Differentiation
Methylation
Histone H3 Acetylation
Gene Silencing
Pathogenesis

V(d)j Recombination

PTMs

Phosphorylation

Acetylation

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/VPREB1

References

PMID: 7935499 by Guelpa-Fonlupt V., et al. The human pre-B cell receptor: structural constraints for a tentative model of the pseudo-light (psi L) chain.

PMID: 9074928 by Kawasaki K., et al. One-megabase sequence analysis of the human immunoglobulin lambda gene locus.