Vacuolar protein sorting-associated protein 54 (VPS54)

Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes into the trans-Golgi network (TGN). The GARP complex is necessary for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is vital for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:18367545).

Within the GARP complex, required to tether the complex to the TGN. Not included in endocytic recycling (PubMed:25799061).