Vacuolar protein sorting-associated protein 8 homolog (VPS8)

Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to work as a part of the putative CORVET endosomal tethering complexes that's proposed to participate in the Rab5-to-Rab7 endosome conversion likely implicating MON1A/B, and through binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion.

The CORVET complex is suggested to be a Rab5 effector to mediate early endosome fusion likely in specific endosome subpopulations (PubMed:25266290). Functions mostly in APPL1-containing endosomes (PubMed:25266290).