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- Table of Contents
WAC Antibodies
AND WAC ELISA kits, WAC Proteins
Many biological assays use antibodies to detect WAC, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with WAC in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop WAC antibodies...
Designing a Western blot for WAC? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the WAC Western Blot GuideWAC Infographic by Boster Bio
All WAC Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A04941-1
100 μg/vial
Cat # A04941-1
100 μg/vial
WAC Overview
Facts about WW domain-containing adapter protein with coiled-coil.
WW domain-containing adapter protein with coiled-coil (WAC)
Acts as a linker between gene transcription and histone H2B monoubiquitination in'Lys-120' (H2BK120ub1) (PubMed:21329877). Interacts with the RNA polymerase II transcriptional machinery via its WW domain name and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription (PubMed:21329877).
Positive regulator of amino acid starvation- induced autophagy (PubMed:22354037). Also acts as a negative regulator of basal autophagy (PubMed:26812014).
Gene Information
| Human | |
|---|---|
| Gene Name: | WAC |
| Uniprot: | Q9BTA9 |
| Entrez: | 51322 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
1110067P07Rik; bA48B24; bA48B24.1; BM-016; FLJ31290; KIAA1844; MGC10753; PRO1741; WW domain containing adaptor with coiled-coil; WW domain-containing adapter protein with coiled-coil; WW domain-containing adaptor with coiled coil; Wwp4
Molecular Weight
Mass (kDA):
70.724 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10p12.1|10p12.1-p11.2 |
| Sequence: | 10; NC_000010.11 (28532772..28623112) |
Subcellular Localizations
Nucleus speckle. Nucleus. In distinct nuclear speckles. Colocalizes with pre-mRNA processing complexes.
Diseases
- Depressive Disorder
- Neoplasms
- Malignant Neoplasms
- Rheumatoid Arthritis
- Arthritis
- Schizophrenia
- Hypertensive Disease
- Agitation
- Arthritis, Adjuvant
- Hepatitis
- Cardiovascular Diseases
- Neuroblastoma
Interacting Proteins
- DYDC1
- HTT
- KLC3
- KRT15
- MTUS2
- NFE2L2
- SYTL5
- TRAF1
- TRAF3IP3
Pathways
- Pathogenesis
- Translation
- Autophagy
- Transport
- Atp-dependent Chromatin Remodeling
- Stem Cell Differentiation
- Immune Response
- Hypersensitivity
- Inflammatory Response
- Cell Division
- Fermentation
- Female Meiosis
- Cell Differentiation
PTMs
- Phosphorylation
- Nitration
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/WAC
bosterbio.com/bosterbio-gene-info-cards/WAC
References
PMID: 22354037 by McKnight N.C., et al. Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC.
PMID: 25356899 by Hamdan F.F., et al. De novo mutations in moderate or severe intellectual disability.