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- Table of Contents

Facts about WW domain-containing adapter protein with coiled-coil.
Positive regulator of amino acid starvation- induced autophagy (PubMed:22354037). Also acts as a negative regulator of basal autophagy (PubMed:26812014).
| Human | |
|---|---|
| Gene Name: | WAC |
| Uniprot: | Q9BTA9 |
| Entrez: | 51322 |

| Belongs to: |
|---|
| No superfamily |

1110067P07Rik; bA48B24; bA48B24.1; BM-016; FLJ31290; KIAA1844; MGC10753; PRO1741; WW domain containing adaptor with coiled-coil; WW domain-containing adapter protein with coiled-coil; WW domain-containing adaptor with coiled coil; Wwp4
Mass (kDA):
70.724 kDA

| Human | |
|---|---|
| Location: | 10p12.1|10p12.1-p11.2 |
| Sequence: | 10; NC_000010.11 (28532772..28623112) |
Nucleus speckle. Nucleus. In distinct nuclear speckles. Colocalizes with pre-mRNA processing complexes.





PMID: 22354037 by McKnight N.C., et al. Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC.
PMID: 25356899 by Hamdan F.F., et al. De novo mutations in moderate or severe intellectual disability.