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WDFY3 Antibodies
AND WDFY3 ELISA kits, WDFY3 Proteins
Many biological assays use antibodies to detect WDFY3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with WDFY3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop WDFY3 antibodies...
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WDFY3 Overview
Facts about WD repeat and FYVE domain-containing protein 3.
WD repeat and FYVE domain-containing protein 3 (WDFY3)
Required for discerning macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, like the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3 (PubMed:20417604).
Together with p62/SQSTM1, involved in the formation and autophagic degradation of cytoplasmic ubiquitin- containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Together with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092).
Gene Information
| Human | |
|---|---|
| Gene Name: | WDFY3 |
| Uniprot: | Q8IZQ1 |
| Entrez: | 23001 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
ALFY; Autophagy-linked FYVE protein; KIAA0993MGC16461; WD repeat and FYVE domain containing 3; WD repeat and FYVE domain-containing protein 3; ZFYVE25
Molecular Weight
Mass (kDA):
395.258 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4q21.23 |
| Sequence: | 4; NC_000004.12 (84669597..84966690, complement) |
Tissue Specificity
Expressed in osteoclast and their mononuclear precursors (at protein level).
Subcellular Localizations
Nucleus membrane. Cytoplasm, cytosol. Nucleus, PML body. Membrane; Peripheral membrane protein; Cytoplasmic side. Perikaryon. Cell projection, axon. Relocalization from the nucleus to the cytosol is stimulated by cellular stress, such as starvation or proteasomal inhibition. In the cytosol of starved cells, colocalizes with autophagic structures (PubMed:15292400, PubMed:20168092, PubMed:20971078, PubMed:20417604). This redistribution is dependent on p62/SQSTM1 (PubMed:20168092). When nuclear export is blocked by treatment with leptomycin B, accumulates in nuclear bodies, that completely or par
Diseases
- Disorders, Late-onset
- Cell Transformation, Neoplastic
- Osteitis Deformans
- Neurodegenerative Disorders
- Chromosome Inversion
- Physiological Stress
- Myopathy
- Malignant Neoplasms
- Leukemia
Interacting Proteins
- ATG5
- CEP76
- GABARAPL1
- GABARAPL2
- HTT
- MAP1LC3B
- MAP1LC3C
- PIK3R3
- TRIM39
- ZBTB44
Pathways
- Autophagy
- Macroautophagy
- Cell Death
- Response To Starvation
- Cell Migration
- Programmed Cell Death
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/WDFY3
bosterbio.com/bosterbio-gene-info-cards/WDFY3
References
PMID: 15292400 by Simonsen A., et al. Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes.
PMID: 20168092 by Clausen T.H., et al. p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy.